This version is easier than previous ones, because you can permanently unlock better starting ships meeting certain criteria. That is your first goal.
Be sure to check the cemetery gates option, let you find in actual run your previous abandoned ships (in previous run).
Don’t be shy to use easy mode to get you acquainted with the mechanics (as far as I know it consumes less fuel).
Move in short distances, never leave a system without fuel and Fe.
Try to get Th (from rocky planets) as soon as you can (it’s needed for T stasis, usually the first tech you will learn).
Always drill and probe at 10 even if they break.
Go to red first (the first on map target) then after you encounter the Monolith, go to green…it’s the easiest ending.
For this, you don’t need specific elements, so don’t lose time drilling other elements.
Never, ever try your luck with events unless you know the outcome or you have your engines upgraded…you could end in a distant system far from everywhere without any possibility to reach any destination.
Those are first tips on top of my head…other endings are more difficult and require specific techs, but you will learn that along the way.
All endings are great imho, and worthy of your time.
Ask you have any other question!!!